Côtes du Roussillon is an Appellation d'Origine Contrôlée for wines made in the Roussillon wine region of France. It is the least selective AOC in the Roussillon region. Grenache is the dominant variety in the Red and Rosé wines. According to the AOC rules, red wines must, though, be made with at least three varieties of grapes. The total of the two main variety grapes should not make more than 90% of the blend, and there must not be more than 60% of Carignan in it.

Côtes du Roussillon wines are made with the traditional variety grapes of the Roussillon, that is Grenache Noir, Grenache Blanc, Carignan, Lladoner Pelut, Cinsault, Macabeu and Malvoisie and with some new to the region variety grapes: Syrah, Mourvèdre, Roussanne, Marsanne (all from Côte du Rhone) and Vermentino (from Italy).

Côtes du Roussillon-Villages is a sub-appellation in the northern half of the appellation in the valley of the river Agly, from the best slopes around the valley. The appellation is in the foothills of the Pyrenees and the better wines are normally produced from vines on the slopes, not in the valley floors. It is purely for red wines.